The AIMS of the Explicit-stroke project are as follows:
  1. Investigate the effects of early interventions for the upper paretic limb post stroke
  2. Exploring dynamics in cerebral plasticity during upper limb recovery after stroke
  3. Improving early prediction of outcome of the upper paretic limb after stroke
  4. Exploring what patients exactly learn when showing functional recovery in the upper paretic limb after stroke.

To accomplish these aims the project is divided into sub-projects A1-2, B1-3, and C.

General research plan for Explicit-stroke

Explicit-stroke has been designed to include four closely inter-related phases and 3 main projects (projects A,B and C).

The two A projects and aim to investigate the effects of CIMT (A1) and EMG-NMS (A2) .

The three B projects are aimed at examining (1) the learning- and time-dependent changes in cortical neuroplasticity after MCA (middle cerebral artery) stroke (B1); (2) the kinematic changes (B2) and (3) the biomechanical changes (B3) related to upper limb recovery in the first 6 months post stroke.

Project C will investigate the longitudinal, quasi-causal relationship between, on the one hand, observed improvements in upper limb function, and, on the other hand, (a) dynamics in cortical plasticity (also B1); (b) changes in body functions and kinematics (also B2) and (c) changes in the stiffness of the paretic upper limb in the first 6 months (alsoB3).

 

Consortium members

 

LUMC

Prof. dr. Hans Arendzen

Dr. Carel Meskers

drs. Hanneke van der Krogt

VUMC

Prof. dr. Gert Kwakkel

Dr. Erwin van Wegen

drs. Joost van Kordelaar

drs. Rinske Nijland

UMCU

Prof. dr. Eline Lindeman

Dr. Anne Visser

drs. Floor Buma

UMC StRadboud

Prof. dr. Alexander Geurts

Dr. Annet van Kuijk

drs. Chantal Bakker

TU Delft

Prof. dr. Frans van der Helm

Dr. E. de Vlugt

drs. Asbjorn Klomp